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Mol Cell Oncol. 2014 Aug 13;1(1):e29914. doi: 10.4161/mco.29914. eCollection 2014.

When defense turns into attack: Antiviral cytidine deaminases linked to somatic mutagenesis in HPV-associated cancer.

Author information

1
Bill Lyons Informatics Centre; UCL Cancer Institute; University College London; London, UK.
2
Department of Oncology; UCL Cancer Institute; University College London; London, UK.

Abstract

The APOBEC3 cytidine deaminases play an important role in innate immunity but have also emerged as mediators of somatic mutations in human cancer. We recently reported a high incidence of APOBEC-mediated driver mutations in human papillomavirus-associated cancer, suggesting a key role for these enzymes in the development of such tumors.

KEYWORDS:

APOBEC; HPV; PIK3CA; cancer; mutagenesis

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