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Bioinformatics. 2016 Jun 15;32(12):i37-i43. doi: 10.1093/bioinformatics/btw249.

Novel applications of multitask learning and multiple output regression to multiple genetic trait prediction.

Author information

1
IBM T.J. Watson Research, Yorktown Heights, NY, USA.
2
USDA-ARS Subtropical Horticultural Research Station, Miami, FL, USA.

Abstract

Given a set of biallelic molecular markers, such as SNPs, with genotype values encoded numerically on a collection of plant, animal or human samples, the goal of genetic trait prediction is to predict the quantitative trait values by simultaneously modeling all marker effects. Genetic trait prediction is usually represented as linear regression models. In many cases, for the same set of samples and markers, multiple traits are observed. Some of these traits might be correlated with each other. Therefore, modeling all the multiple traits together may improve the prediction accuracy. In this work, we view the multitrait prediction problem from a machine learning angle: as either a multitask learning problem or a multiple output regression problem, depending on whether different traits share the same genotype matrix or not. We then adapted multitask learning algorithms and multiple output regression algorithms to solve the multitrait prediction problem. We proposed a few strategies to improve the least square error of the prediction from these algorithms. Our experiments show that modeling multiple traits together could improve the prediction accuracy for correlated traits.

AVAILABILITY AND IMPLEMENTATION:

The programs we used are either public or directly from the referred authors, such as MALSAR (http://www.public.asu.edu/~jye02/Software/MALSAR/) package. The Avocado data set has not been published yet and is available upon request.

CONTACT:

dhe@us.ibm.com.

PMID:
27307640
PMCID:
PMC4908333
DOI:
10.1093/bioinformatics/btw249
[Indexed for MEDLINE]
Free PMC Article

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