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Can J Neurol Sci. 2016 Apr;43 Suppl 1:S51-82. doi: 10.1017/cjn.2016.36.

The Prevalence and Incidence of Dementia Due to Alzheimer's Disease: a Systematic Review and Meta-Analysis.

Author information

1
1Department of Community Health Sciences,University of Calgary,Calgary,Alberta,Canada.
2
7Brenda Strafford Chair in Geriatric Medicine,University of Calgary,Calgary,Alberta,Canada.
3
8Department of Medicine,Cumming School of Medicine,University of Calgary,Calgary,Alberta,Canada.
4
9Department of Medicine,University of Saskatchewan,Saskatoon,Saskatchewan,Canada.
5
3Hotchkiss Brain Institute,University of Calgary,Calgary,Alberta,Canada.

Abstract

BACKGROUND:

Updated information on the epidemiology of dementia due to Alzheimer's disease (AD) is needed to ensure that adequate resources are available to meet current and future healthcare needs. We conducted a systematic review and meta-analysis of the incidence and prevalence of AD.

METHODS:

The MEDLINE and EMBASE databases were searched from 1985 to 2012, as well as the reference lists of selected articles. Included articles had to provide an original population-based estimate for the incidence and/or prevalence of AD. Two individuals independently performed abstract and full-text reviews, data extraction and quality assessments. Random-effects models were employed to generate pooled estimates stratified by age, sex, diagnostic criteria, location (i.e., continent) and time (i.e., when the study was done).

RESULTS:

Of 16,066 abstracts screened, 707 articles were selected for full-text review. A total of 119 studies met the inclusion criteria. In community settings, the overall point prevalence of dementia due to AD among individuals 60+ was 40.2 per 1000 persons (CI95%: 29.1-55.6), and pooled annual period prevalence was 30.4 per 1000 persons (CI95%: 15.6-59.1). In community settings, the overall pooled annual incidence proportion of dementia due to AD among individuals 60+ was 34.1 per 1000 persons (CI95%: 16.4-70.9), and the incidence rate was 15.8 per 1000 person-years (CI95%: 12.9-19.4). Estimates varied significantly with age, diagnostic criteria used and location (i.e., continent).

CONCLUSIONS:

The burden of AD dementia is substantial. Significant gaps in our understanding of its epidemiology were identified, even in a high-income country such as Canada. Future studies should assess the impact of using such newer clinical diagnostic criteria for AD dementia such as those of the National Institute on Aging-Alzheimer's Association and/or incorporate validated biomarkers to confirm the presence of Alzheimer pathology to produce more precise estimates of the global burden of AD.

KEYWORDS:

Alzheimer’s; dementia; meta-analysis; systematic review

PMID:
27307128
DOI:
10.1017/cjn.2016.36
[Indexed for MEDLINE]

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