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Biochem Biophys Res Commun. 1989 May 15;160(3):1162-8.

Mechanisms of reoxygenation injury in myocardial infarction: implications of a myoglobin redox cycle.

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Institute for Toxicology, University of Southern California, Los Angeles 90033.


The addition of ascorbate to ischemic rat hearts prevents the myocardial damage associated with reoxygenation. H2O2 oxidizes myoglobin (Mb+2) to higher oxidation states (Mb+4 and Mb+5) which are rapidly reduced by ascorbate. It is proposed that the operation of a myoglobin redox cycle, in which H2O2 causes the two-electron oxidation of myoglobin, is a critical determinant of reperfusion injury. Conversely, the reduction of myoglobin, in one-electron steps, may represent an essential protective mechanism against such injury in the heart.

[Indexed for MEDLINE]

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