Format

Send to

Choose Destination
Biochem Biophys Res Commun. 1989 May 15;160(3):1162-8.

Mechanisms of reoxygenation injury in myocardial infarction: implications of a myoglobin redox cycle.

Author information

1
Institute for Toxicology, University of Southern California, Los Angeles 90033.

Abstract

The addition of ascorbate to ischemic rat hearts prevents the myocardial damage associated with reoxygenation. H2O2 oxidizes myoglobin (Mb+2) to higher oxidation states (Mb+4 and Mb+5) which are rapidly reduced by ascorbate. It is proposed that the operation of a myoglobin redox cycle, in which H2O2 causes the two-electron oxidation of myoglobin, is a critical determinant of reperfusion injury. Conversely, the reduction of myoglobin, in one-electron steps, may represent an essential protective mechanism against such injury in the heart.

PMID:
2730642
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center