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Adv Mater. 2016 Sep;28(33):7257-63. doi: 10.1002/adma.201601484. Epub 2016 Jun 15.

Sliding Hydrogels with Mobile Molecular Ligands and Crosslinks as 3D Stem Cell Niche.

Author information

1
Department of Orthopaedic Surgery, Stanford University School of Medicine, CA, 94305, USA.
2
Departments of Orthopaedic Surgery and Bioengineering, Stanford University School of Medicine, 300 Pasteur Dr, Edwards R105, CA, 94305, USA.

Abstract

The development of a sliding hydrogel with mobile crosslinks and biochemical ligands as a 3D stem cell niche is reported. The molecular mobility of this sliding hydrogel allows stem cells to reorganize the surrounding ligands and change their morphology in 3D. Without changing matrix stiffness, sliding hydrogels support efficient stem cell differentiation toward multiple lineages including adipogenesis, chondrogenesis, and osteogenesis.

KEYWORDS:

cell niches; cyclodextrins; sliding hydrogels

PMID:
27305637
PMCID:
PMC5127628
DOI:
10.1002/adma.201601484
[Indexed for MEDLINE]
Free PMC Article

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