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Exp Dermatol. 2017 Feb;26(2):137-144. doi: 10.1111/exd.13115. Epub 2016 Nov 16.

IL-17A promotes neutrophilic inflammation and disturbs acute wound healing in skin.

Author information

1
Department of Plastic and Reconstructive Surgery, Tohoku University, Sendai, Japan.
2
Department of Medical Microbiology, Mycology and Immunology, Tohoku University, Sendai, Japan.
3
Department of Science of Nursing Practice, Tohoku University, Sendai, Japan.
4
Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Japan.

Abstract

In the wound healing process, neutrophils are the first inflammatory cells to move to the wound tissues. They sterilize wounds by killing microbes, and they stimulate other immune cells to protect the host from infection. In contrast, neutrophil-derived proteases cause damage to host tissues, so neutrophils play dual opposite roles in wound healing. Interleukin-17A (IL-17A) is a proinflammatory cytokine that promotes the recruitment of these cells. The role of this cytokine in the wound healing process is not fully clarified. In the present study, therefore, we examined how defect in IL-17A production affected the wound healing in skin. IL-17A-knockout (KO) mice showed promoted wound closure, myofibroblast differentiation and collagen deposition and decreased the neutrophil accumulation compared with wild-type (WT) mice. In contrast, the administration of recombinant IL-17A led to delayed wound closure, low collagen deposition and accelerated neutrophilic accumulation. In addition, the treatment of IL-17A-administered mice with a neutrophil elastase inhibitor improved the wound repair to the same level as that of WT mice. These results indicated that IL-17A hampered the wound healing process and suggested that neutrophilic inflammation caused by IL-17A may be associated with impaired wound healing in skin.

KEYWORDS:

IL-17A; neutrophil; wound healing

PMID:
27305096
DOI:
10.1111/exd.13115
[Indexed for MEDLINE]

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