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Cell Metab. 2016 Jun 14;23(6):1060-1065. doi: 10.1016/j.cmet.2016.05.011.

Metformin as a Tool to Target Aging.

Author information

1
Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: nir.barzilai@einstein.yu.edu.
2
Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
3
Wake Forest Older Americans Independence Center and the Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

Abstract

Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.

PMID:
27304507
PMCID:
PMC5943638
DOI:
10.1016/j.cmet.2016.05.011
[Indexed for MEDLINE]
Free PMC Article

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