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Cell Metab. 2016 Jun 14;23(6):1013-1021. doi: 10.1016/j.cmet.2016.05.010.

From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence.

Author information

1
Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA. Electronic address: cwiley@buckinstitute.org.
2
Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA; Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA. Electronic address: jcampisi@buckinstitute.org.

Abstract

Cellular senescence is a complex stress response that permanently arrests the proliferation of cells at risk for oncogenic transformation. However, senescent cells can also drive phenotypes associated with aging. Although the senescence-associated growth arrest prevents the development of cancer, and the metabolism of cancer cells has been studied in depth, the metabolic causes and consequences of cellular senescence were largely unexplored until recently. New findings reveal key roles for several aspects of cellular metabolism in the establishment and control of senescent phenotypes. These discoveries have important implications for both cancer and aging. In this review, we highlight some of the recent links between metabolism and phenotypes that are commonly associated with senescent cells.

PMID:
27304503
PMCID:
PMC4911819
DOI:
10.1016/j.cmet.2016.05.010
[Indexed for MEDLINE]
Free PMC Article

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