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Cell Metab. 2016 Jun 14;23(6):965-966. doi: 10.1016/j.cmet.2016.05.022.

Why NAD(+) Declines during Aging: It's Destroyed.

Author information

1
Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
2
Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Pharmacology, University of New South Wales, Sydney 2052, Australia. Electronic address: david_sinclair@hms.harvard.edu.

Abstract

NAD(+) is required not only for life but for a long life. In this issue, Camacho-Pereira et al. (2016) implicate CD38 in the decline of NAD(+) during aging, with implications for combating age-related diseases.

PMID:
27304496
PMCID:
PMC5088772
DOI:
10.1016/j.cmet.2016.05.022
[Indexed for MEDLINE]
Free PMC Article

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