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Basic Clin Neurosci. 2016 Apr;7(2):81-90. doi: 10.15412/J.BCN.03070201.

Polyphenolic Antioxidants and Neuronal Regeneration.

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Cellular and Molecular Research Center, Babol University of Medical Sciences, Babol, Iran.
Amol Center, Pasteur Institute of Iran, Amol, Iran.
Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran.


Many studies indicate that oxidative stress is involved in the pathophysiology of neurodegenerative diseases. Oxidative stress can induce neuronal damages, modulate intracellular signaling and ultimately leads to neuronal death by apoptosis or necrosis. To review antioxidants preventive effects on oxidative stress and neurodegenerative diseases we accumulated data from international medical journals and academic informations' sites. According to many studies, antioxidants could reduce toxic neuronal damages and many studies confirmed the efficacy of polyphenol antioxidants in fruits and vegetables to reduce neuronal death and to diminish oxidative stress. This systematic review showed the antioxidant activities of phytochemicals which play as natural neuroprotectives with low adverse effects against some neurodegenerative diseases as Parkinson or Alzheimer diseases.


Alzheimer; Curcumin; Oxidative stress; Resveratrol

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