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Proc SPIE Int Soc Opt Eng. 2016 Feb 27;9784. pii: 97840P. Epub 2016 Mar 21.

Landmark Based Shape Analysis for Cerebellar Ataxia Classification and Cerebellar Atrophy Pattern Visualization.

Author information

  • 1Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
  • 2Electrical and Computer Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
  • 3The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
  • 4Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD 21218, USA.
  • 5Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD 21218, USA; The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.

Abstract

Cerebellar dysfunction can lead to a wide range of movement disorders. Studying the cerebellar atrophy pattern associated with different cerebellar disease types can potentially help in diagnosis, prognosis, and treatment planning. In this paper, we present a landmark based shape analysis pipeline to classify healthy control and different ataxia types and to visualize the characteristic cerebellar atrophy patterns associated with different types. A highly informative feature representation of the cerebellar structure is constructed by extracting dense homologous landmarks on the boundary surfaces of cerebellar sub-structures. A diagnosis group classifier based on this representation is built using partial least square dimension reduction and regularized linear discriminant analysis. The characteristic atrophy pattern for an ataxia type is visualized by sampling along the discriminant direction between healthy controls and the ataxia type. Experimental results show that the proposed method can successfully classify healthy controls and different ataxia types. The visualized cerebellar atrophy patterns were consistent with the regional volume decreases observed in previous studies, but the proposed method provides intuitive and detailed understanding about changes of overall size and shape of the cerebellum, as well as that of individual lobules.

KEYWORDS:

Cerebellar ataxia; atrophy pattern; landmarks; linear discriminant analysis; magnetic resonance images; partial least squares; shape analysis; visualization

PMID:
27303111
PMCID:
PMC4903164
DOI:
10.1117/12.2217313
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