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PLoS Biol. 2016 Jun 14;14(6):e1002477. doi: 10.1371/journal.pbio.1002477. eCollection 2016 Jun.

Authentication: A Standard Problem or a Problem of Standards?

Author information

1
CellBank Australia-Children's Medical Research Institute, Westmead, New South Wales, Australia.
2
Gilead Sciences Inc, Foster City, California, United States of America.

Abstract

Reproducibility and transparency in biomedical sciences have been called into question, and scientists have been found wanting as a result. Putting aside deliberate fraud, there is evidence that a major contributor to lack of reproducibility is insufficient quality assurance of reagents used in preclinical research. Cell lines are widely used in biomedical research to understand fundamental biological processes and disease states, yet most researchers do not perform a simple, affordable test to authenticate these key resources. Here, we provide a synopsis of the problems we face and how standards can contribute to an achievable solution.

PMID:
27300550
PMCID:
PMC4907433
DOI:
10.1371/journal.pbio.1002477
[Indexed for MEDLINE]
Free PMC Article

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