Mouse Models Applied to the Research of Pharmacological Treatments in Asthma

Methods Mol Biol. 2016:1434:239-53. doi: 10.1007/978-1-4939-3652-6_17.

Abstract

Models developed for the study of asthma mechanisms can be used to investigate new compounds with pharmacological activity against this disease. The increasing number of compounds requires a preclinical evaluation before starting the application in humans. Preclinical evaluation in animal models reduces the number of clinical trials positively impacting in the cost and in safety. In this chapter, three protocols for the study of drugs are shown: a model to investigate corticoids as a classical treatment of asthma; a protocol to test the effects of retinoic acid (RA) on asthma; and a mouse model to test new therapies in asthma as monoclonal antibodies.

Keywords: Animal model; Antibody; Corticoids; Monoclonal; Mouse.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage*
  • Adrenal Cortex Hormones / therapeutic use
  • Animals
  • Antibodies, Monoclonal / administration & dosage*
  • Antibodies, Monoclonal / therapeutic use
  • Asthma / drug therapy*
  • Asthma / immunology
  • Disease Models, Animal*
  • Drug Evaluation, Preclinical
  • Female
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Research Design
  • Tretinoin / administration & dosage*
  • Tretinoin / therapeutic use

Substances

  • Adrenal Cortex Hormones
  • Antibodies, Monoclonal
  • Tretinoin