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CPT Pharmacometrics Syst Pharmacol. 2016 May;5(5):235-49. doi: 10.1002/psp4.12071. Epub 2016 Apr 16.

A Six-Stage Workflow for Robust Application of Systems Pharmacology.

Author information

  • 1Translational & Systems Pharmacology, PKPD, Genentech, South San Francisco, California, USA.
  • 2Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York.
  • 3Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • 4Certara QSP, Canterbury, UK.

Abstract

Quantitative and systems pharmacology (QSP) is increasingly being applied in pharmaceutical research and development. One factor critical to the ultimate success of QSP is the establishment of commonly accepted language, technical criteria, and workflows. We propose an integrated workflow that bridges conceptual objectives with underlying technical detail to support the execution, communication, and evaluation of QSP projects.

PMID:
27299936
PMCID:
PMC4879472
DOI:
10.1002/psp4.12071
[PubMed - in process]
Free PMC Article
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