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CPT Pharmacometrics Syst Pharmacol. 2016 May;5(5):235-49. doi: 10.1002/psp4.12071. Epub 2016 Apr 16.

A Six-Stage Workflow for Robust Application of Systems Pharmacology.

Author information

1
Translational & Systems Pharmacology, PKPD, Genentech, South San Francisco, California, USA.
2
Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York.
3
Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
4
Certara QSP, Canterbury, UK.

Abstract

Quantitative and systems pharmacology (QSP) is increasingly being applied in pharmaceutical research and development. One factor critical to the ultimate success of QSP is the establishment of commonly accepted language, technical criteria, and workflows. We propose an integrated workflow that bridges conceptual objectives with underlying technical detail to support the execution, communication, and evaluation of QSP projects.

PMID:
27299936
PMCID:
PMC4879472
DOI:
10.1002/psp4.12071
[Indexed for MEDLINE]
Free PMC Article

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