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Head Neck. 2017 Jan;39(1):37-41. doi: 10.1002/hed.24525. Epub 2016 Jun 14.

Excessive intravenous fluid therapy in head and neck cancer surgery.

Author information

1
Department of Otorhinolaryngology, Turku University Hospital and University of Turku, Turku, Finland.
2
Heart Center, Turku University Hospital and University of Turku, Turku, Finland.

Abstract

BACKGROUND:

The purpose of this retrospective study was to present our assessment of modifiable perioperative factors for major cardiac and cerebrovascular events (MACCE).

METHODS:

This study included an unselected cohort of patients with head and neck cancer (n = 456) treated in Turku University Hospital between 1999 and 2008.

RESULTS:

Perioperative and postoperative univariate predictors of MACCE at 30-day follow-up were: total amount of fluids (during 24 hours) over 4000 mL, any red blood cell (RBC) infusion, treatment in the intensive care unit (ICU), tracheostomy, and microvascular reconstruction surgery. Median time from operation to MACCE was 3 days. Patients receiving >4000 mL of fluids had MACCE more often compared with those receiving <4000 mL (10.8% vs 2.4%; p < .001, respectively). Moreover, every RBC unit transfused or every liter of fluid administered over 4000 mL/24h increased the risk of MACCE 18% per unit/liter, respectively.

CONCLUSION:

Patients with head and neck cancer receiving excessive intravenous fluid administration perioperatively and postoperatively are at high risk for cardiac complications, especially heart failure. © 2016 Wiley Periodicals, Inc. Head Neck 39: 37-41, 2017.

KEYWORDS:

cardiovascular complication; head and neck cancer; perioperative fluid management; red blood cell; transfusion

PMID:
27299857
DOI:
10.1002/hed.24525
[Indexed for MEDLINE]

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