Format

Send to

Choose Destination
J Pediatr Orthop. 2018 Mar;38(3):144-151. doi: 10.1097/BPO.0000000000000799.

The Final 24-Item Early Onset Scoliosis Questionnaires (EOSQ-24): Validity, Reliability and Responsiveness.

Author information

1
Department of Orthopaedic Surgery, Columbia University Medical Center.
2
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.
3
Department of Orthopaedics and Rehabilitation, University of Florida, Gainesville, FL.
4
Department of Orthopaedic Surgery, David Geffen School of Medicine at University of California at Los Angeles.
5
Department of Orthopaedics, University of California, San Diego, La Jolla, CA.
6
Department of Orthopaedic Surgery, Children's Hospital, Harvard Medical School, Boston, MA.
7
Children's Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles.
8
Department of Orthopaedics and Pediatrics, Primary Children's Medical Center, The University of Utah School of Medicine, Salt Lake City, UT.

Abstract

INTRODUCTION:

The goal of early-onset scoliosis (EOS) treatment is to improve health-related quality of life (HRQoL) for patients and to reduce the burden on their parents or caregivers. The purpose of this study is to develop and finalize the 24-item Early-Onset Scoliosis Questionnaire (EOSQ-24), and examine the validity, reliability, and responsiveness of the EOSQ-24 in measuring patients' HRQoL, the burden on their caregivers, and the burden on their caregiver's finances. The study also established aged-matched normative values for the EOSQ-24.

METHODS:

The EOSQ-24 was administered to caregivers of male and female patients aged 0 to 18 years with EOS. Patients with EOS are diagnosed before 10 years of age. Criterion validity was investigated by measuring agreement between its scores and pulmonary function testing. Construct validity was established by comparing values across different etiology groups using the known-group method, and measuring internal consistency reliability. Content validity was confirmed by reviewing caregiver and health provider ratings for the relativity and clarity of the EOSQ-24 questions. Test-retest reliability was examined through intraclass correlation coefficients. Responsiveness of the EOSQ-24 before and after surgical interventions was also investigated. Age-matched, healthy patients, without spinal deformity, were enrolled to establish normative EOSQ-24 values.

RESULTS:

The pulmonary function subdomain score in the EOSQ-24 was positively correlated with pulmonary function testing values, establishing criterion validity. The EOSQ-24 scores for neuromuscular patients were significantly decreased compared with idiopathic or congenital/structural patients, demonstrating known-group validity. Internal consistency reliability of patients' HRQoL was excellent (0.92), but Family Burden was questionable (0.64) indicating that Parental Burden and Financial Burden should be in separate domains. All 24 EOSQ items were rated as essential and clear, confirming content validity. All EOSQ-24 domains demonstrated good to excellent agreement (0.68 to 0.98) between test and retest scores. Neuromuscular patients improved their HRQoL postoperatively, whereas idiopathic patients worsened their HRQoL postoperatively, indicating the ability of the instrument to respond to different trajectories of HRQoL according to etiology in patients with EOS.

DISCUSSION:

The developed and finalized EOSQ-24 is a valid, reliable, and responsive instrument that is able to serve as a patient-reported outcome measure evaluating health status for patients with EOS and burden of their caregivers. This instrument will be able to serve as an outcome measure for future research including clinical trials evaluating the effectiveness of various treatments. In addition, the EOSQ-24 allows assessment of patients' HRQoL, and the burden on their caregivers relative to age-matched healthy peers.

LEVEL OF EVIDENCE:

Level II-diagnostic study with consecutive patients enrolled in national registries.

PMID:
27299779
PMCID:
PMC5562528
[Available on 2019-03-01]
DOI:
10.1097/BPO.0000000000000799
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center