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Mediators Inflamm. 2016;2016:5797930. doi: 10.1155/2016/5797930. Epub 2016 May 19.

Macrophage Migration Inhibitory Factor and Malondialdehyde as Potential Predictors of Vascular Risk Complications in Type 2 Diabetes Mellitus: Cross-Sectional Case Control Study in Saudi Arabia.

Author information

1
Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt; Laboratory Medicine Department, College of Applied Medical Science, Umm Al Qura University, Makkah 21955, Saudi Arabia.
2
Laboratory Medicine Department, College of Applied Medical Science, Umm Al Qura University, Makkah 21955, Saudi Arabia; Clinical Pathology Department, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
3
Clinical Pathology Department, Al Azhar University, Cairo 11651, Egypt; Clinical Chemistry Department, Al Noor Specialist Hospital, Makkah 21955, Saudi Arabia.
4
Cancer Epidemiology and Biostatistics Department, National Cancer Institute, Cairo University, Cairo 11796, Egypt; Kuwait Cancer Registry, 70653 Kuwait, Kuwait.

Abstract

BACKGROUND:

Malondialdehyde (MDA) has been implicated in the development of many acute inflammatory, autoimmune diseases as well as chronic inflammatory metabolic disorders. Involvement of inflammatory response and oxidative stress is currently suggested as a mechanism underlying development of diabetes and its complications.

OBJECTIVE:

To evaluate the clinical utility of MDA, macrophage migration inhibitory factor (MIF), LDL-C/HDL-C, and TG/HDL-C ratio as noninvasive laboratory markers for prediction of T2DM vascular complications.

METHOD:

63 Saudi T2DM patients and 16 age and sex matched controls were included. Serum MDA and MIF were assayed by thiobarbituric acid reactive substances and ELISA, respectively. TG/HDL-C and LDL-C/HDL-C ratios were calculated.

RESULTS:

Uncontrolled DM patients had significantly higher levels of MDA, MIF, TG/HDL-C, and LDL-C/HDL-C ratios when compared with controlled DM patients and control group (p < 0.001). MDA had 100% sensitivity and 88% specificity. MIF showed 97% sensitivity and 100% specificity and LDL-C/HDL-C had 97% sensitivity and 95% specificity. Meanwhile, TG/HDL-C had the lowest sensitivity and specificity in identifying diabetic patients who would suffer from vascular complications.

CONCLUSION:

MDA, MIF, and LDL-C/HDL-C could be new predictors of metabolic disturbance which promote vascular complications in T2DM.

PMID:
27298517
PMCID:
PMC4889835
DOI:
10.1155/2016/5797930
[Indexed for MEDLINE]
Free PMC Article

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