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Indian J Pharmacol. 2016 May-Jun;48(3):312-5. doi: 10.4103/0253-7613.182880.

Anabolic therapy with Equisetum arvense along with bone mineralising nutrients in ovariectomized rat model of osteoporosis.

Author information

1
University Department of Biochemistry, RTM Nagpur University, Nagpur, Maharashtra, India.

Abstract

OBJECTIVE:

Equisetum arvense has been used to treat bone diseases. The traditional supplementation of calcium and Vitamin D for osteoporosis patients is insufficient considering the rise in patients every year. We have observed that extending the calcium and Vitamin D supplement with L-lysine, L-proline, L-arginine, and L-ascorbic acid (N) positively affects bone mineralization in ovariectomized rat. Here, we report a further extension of the above supplement with E. arvense.

MATERIALS AND METHODS:

The changes in serum biomarkers, bone mineral content, and femur bone histology were studied and compared to the standard drug for osteoporosis, namely raloxifene (RAL).

RESULTS:

We report a significant change in formation and resorption markers of bone as well as in cortical bone thickness and trabecular width in N and N + EA groups. The treatment N + EA also restored lipid profile near to normal level compared to ovariectomized group.

CONCLUSIONS:

Treatment N + EA was found to be as effective as RAL in reversing the osteoporotic changes.

KEYWORDS:

Bone mineralizing nutrients; Equisetum arvense; osteoporosis prevention

PMID:
27298503
PMCID:
PMC4900006
DOI:
10.4103/0253-7613.182880
[Indexed for MEDLINE]
Free PMC Article

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