Metabolic Effects of Obesity and Its Interaction with Endocrine Diseases

Vet Clin North Am Small Anim Pract. 2016 Sep;46(5):797-815. doi: 10.1016/j.cvsm.2016.04.004. Epub 2016 Jun 11.

Abstract

Obesity in pet dogs and cats is a significant problem in developed countries, and seems to be increasing in prevalence. Excess body fat has adverse metabolic consequences, including insulin resistance, altered adipokine secretion, changes in metabolic rate, abnormal lipid metabolism, and fat accumulation in visceral organs. Obese cats are predisposed to endocrine and metabolic disorders such as diabetes and hepatic lipidosis. A connection likely also exists between obesity and diabetes mellitus in dogs. No system has been developed to identify obese pets at greatest risk for development of obesity-associated metabolic diseases, and further study in this area is needed.

Keywords: Adipocytokines; Canine; Diabetes; Dyslipidemia; Feline; Hepatic lipidosis; Insulin resistance; Obesity.

Publication types

  • Review

MeSH terms

  • Adipose Tissue
  • Animals
  • Body Composition
  • Cat Diseases / pathology*
  • Cats
  • Diabetes Mellitus, Type 2 / etiology
  • Diabetes Mellitus, Type 2 / pathology
  • Diabetes Mellitus, Type 2 / veterinary*
  • Dog Diseases / pathology*
  • Dogs
  • Obesity / complications
  • Obesity / veterinary*