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Mol Biochem Parasitol. 2016 Jul;208(1):33-40. doi: 10.1016/j.molbiopara.2016.06.003. Epub 2016 Jun 11.

Host parasite communications-Messages from helminths for the immune system: Parasite communication and cell-cell interactions.

Author information

1
Institute for Immunology and Infection Research, and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, UK.
2
Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunology and Inflammation, University of Glasgow, 120 University Place, Glasgow, G12 8TA, UK. Electronic address: rick.maizels@glasgow.ac.uk.

Abstract

Helminths are metazoan organisms many of which have evolved parasitic life styles dependent on sophisticated manipulation of the host environment. Most notably, they down-regulate host immune responses to ensure their own survival, by exporting a range of immuno-modulatory mediators that interact with host cells and tissues. While a number of secreted immunoregulatory parasite proteins have been defined, new work also points to the release of extracellular vesicles, or exosomes, that interact with and manipulate host gene expression. These recent results are discussed in the overall context of how helminths communicate effectively with the host organism.

KEYWORDS:

Parasite communications

PMID:
27297184
PMCID:
PMC5008435
DOI:
10.1016/j.molbiopara.2016.06.003
[Indexed for MEDLINE]
Free PMC Article

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