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Chromosome Res. 2016 Sep;24(3):393-405. doi: 10.1007/s10577-016-9529-5. Epub 2016 Jun 13.

The distribution of α-kleisin during meiosis in the holocentromeric plant Luzula elegans.

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Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, 06466, Stadt Seeland, Germany.
Institute of Bioinformatics and Systems Biology/Munich Information Center for Protein Sequences, Helmholtz Center Munich, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
Division of Cell Biology, Department of Clinical and Experimental Medicine, Bioinformatics Infrastructure for Life Sciences, Linköping University, 558185, Linköping, Sweden.
Biocenter, Microscopy Unit, Martin Luther University Halle-Wittenberg, Weinbergweg 22, 06120, Halle, Germany.
State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101, Beijing, China.
Leibniz Institute on Aging-Fritz-Lipmann-Institut e.V. (FLI), Beutenbergstraße 11, 07745, Jena, Germany.
Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, 06466, Stadt Seeland, Germany.


Holocentric chromosomes occur in a number of independent eukaryotic lineages, and they form holokinetic kinetochores along the entire poleward chromatid surfaces. Due to this alternative chromosome structure, Luzula elegans sister chromatids segregate already in anaphase I followed by the segregation of the homologues in anaphase II. However, not yet known is the localization and dynamics of cohesin and the structure of the synaptonemal complex (SC) during meiosis. We show here that the α-kleisin subunit of cohesin localizes at the centromeres of both mitotic and meiotic metaphase chromosomes and that it, thus, may contribute to assemble the centromere in L. elegans. This localization and the formation of a tripartite SC structure indicate that the prophase I behaviour of L. elegans is similar as in monocentric species.


CENH3; Holocentric chromosome; Luzula elegans; Synaptonemal complex; α-kleisin

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