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Molecules. 2016 Jun 11;21(6). pii: E752. doi: 10.3390/molecules21060752.

Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine.

Author information

1
Istituto Farmaceutico Candioli, Beinasco (To) 10092, Italy. natascia.bruni@candioli.it.
2
Department of Veterinary Sciences, University of Torino, Torino 10095, Italy. mariateresa.capucchio@unito.it.
3
Department of Veterinary Sciences, University of Torino, Torino 10095, Italy. elena.biasibetti@unito.it.
4
Department of Life Sciences and Systems Biology, University of Torino, Torino 10123, Italy. enrica.pessione@unito.it.
5
Department of Life Sciences and Systems Biology, University of Torino, Torino 10123, Italy. simona.cirrincione@unito.it.
6
Istituto Farmaceutico Candioli, Beinasco (To) 10092, Italy. leonardo.giraudo@candioli.it.
7
Ambulatorio Veterinario Associato, Torino 10135, Italy. antonio@ambulatorioveterinario.eu.
8
Department of Drug Science and Technology, University of Torino, Torino 10125, Italy. franco.dosio@unito.it.

Abstract

Antimicrobial peptides (AMPs) represent a vast array of molecules produced by virtually all living organisms as natural barriers against infection. Among AMP sources, an interesting class regards the food-derived bioactive agents. The whey protein lactoferrin (Lf) is an iron-binding glycoprotein that plays a significant role in the innate immune system, and is considered as an important host defense molecule. In search for novel antimicrobial agents, Lf offers a new source with potential pharmaceutical applications. The Lf-derived peptides Lf(1-11), lactoferricin (Lfcin) and lactoferrampin exhibit interesting and more potent antimicrobial actions than intact protein. Particularly, Lfcin has demonstrated strong antibacterial, anti-fungal and antiparasitic activity with promising applications both in human and veterinary diseases (from ocular infections to osteo-articular, gastrointestinal and dermatological diseases).

KEYWORDS:

antimicrobial peptides; food safety; lactoferricin; milk proteins

PMID:
27294909
PMCID:
PMC6273662
DOI:
10.3390/molecules21060752
[Indexed for MEDLINE]
Free PMC Article

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