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IEEE J Sel Top Quantum Electron. 2016 May-Jun;22(3). pii: 6803507. Epub 2016 Feb 8.

Acoustic Radiation Force Optical Coherence Elastography of Corneal Tissue.

Author information

1
Department of Biomedical Engineering, the Edwards Life Sciences Center for Advanced Cardiovascular Technology, and Beckman Laser Institute, University of California, Irvine, Irvine, CA 92697 USA.
2
NIH Ultrasonic Transducer Resource Center and the Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
3
Beckman Laser Institute, University of California, Irvine, Irvine, CA 92612 USA.
4
Beckman Laser Institute, University of California, Irvine, Irvine, CA 92612 USA, and the Shanghai Institute of Technology, 100 Haiquan Road, Fengxian, Shanghai, China.
5
Beckman Laser Institute, University of California, Irvine, Irvine 92612 USA and the School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 325027 China.
6
School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 325027 China.

Abstract

We report on a real-time acoustic radiation force optical coherence elastography (ARF-OCE) system to map the relative elasticity of corneal tissue. A modulated ARF is used as excitation to vibrate the cornea while OCE serves as detection of tissue response. To show feasibility of detecting mechanical contrast using this method, we performed tissue-equivalent agarose phantom studies with inclusions of a different stiffness. We obtained 3-D elastograms of a healthy cornea and a highly cross-linked cornea. Finally we induced a stiffness change on a small portion of a cornea and observed the differences in displacement.

KEYWORDS:

ARF; OCT; cornea; elastography

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