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Allergy. 2016 Oct;71(10):1496-500. doi: 10.1111/all.12957. Epub 2016 Jul 20.

Atopic dermatitis is not independently associated with nonfatal myocardial infarction or stroke among US women.

Drucker AM1,2,3, Li WQ1,4, Cho E1,4,5, Li T5, Sun Q5,6, Camargo CA Jr5,7,8, Qureshi AA9,10,11,12.

Author information

1
Department of Dermatology, Warren Alpert Medical School, Providence, RI, USA.
2
Department of Dermatology, Rhode Island Hospital, Providence, RI, USA.
3
School of Public Health, Brown University, Providence, RI, USA.
4
Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.
5
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
6
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
7
Department of Emergency Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
8
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
9
Department of Dermatology, Warren Alpert Medical School, Providence, RI, USA. abrar_qureshi@brown.edu.
10
Department of Dermatology, Rhode Island Hospital, Providence, RI, USA. abrar_qureshi@brown.edu.
11
Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA. abrar_qureshi@brown.edu.
12
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. abrar_qureshi@brown.edu.

Abstract

We aimed to determine the association between atopic dermatitis (AD) and cardiovascular events in the Nurses' Health Study 2, a cohort of US women. We used logistic regression models to calculate age- and multivariate-adjusted odds ratios (OR) and 95% confidence intervals (CI) for the associations between history of AD and nonfatal MI and nonfatal stroke. Of the 78 702 participants in our analysis, 7916 (10%) had a history of AD. There were 392 and 391 cases of nonfatal MI and stroke, respectively. AD was not associated with MI in age- or multivariate-adjusted analyses. AD was significantly associated with stroke in the age-adjusted analysis (OR 1.38, 95% CI 1.03-1.85). This was no longer significant in multivariate models that adjusted for hypertension, hypercholesterolemia and diabetes (OR 1.31, 95% CI 0.98-1.76) and atopic comorbidities (OR 1.17, 95% CI 0.86-1.58). AD was not independently associated with nonfatal MI or stroke in this study.

KEYWORDS:

atopic dermatitis; cardiovascular disease; comorbidity; myocardial infarction; stroke

PMID:
27291834
PMCID:
PMC5023476
DOI:
10.1111/all.12957
[Indexed for MEDLINE]
Free PMC Article

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