Format

Send to

Choose Destination
Dev Cogn Neurosci. 2016 Aug;20:2-11. doi: 10.1016/j.dcn.2016.05.002. Epub 2016 May 14.

Connectome hubs at resting state in children and adolescents: Reproducibility and psychopathological correlation.

Author information

1
Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, Santo Andre, Brazil; Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil; Department of Radiology, School of Medicine, University of Sao Paulo, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil. Electronic address: joao.sato@ufabc.edu.br.
2
Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, Santo Andre, Brazil; Department of Radiology, School of Medicine, University of Sao Paulo, Brazil.
3
Department of Psychiatry, Federal University of Rio Grande do Sul and Psychiatric Service, Hospital de Clinicas de Porto Alegre, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
4
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
5
Institute of Psychiatry, King's College London, United Kingdom; Institute for Biological and Medical Engineering, Faculties of Engineering, Medicine and Biological Sciences, P. Catholic University of Chile, Chile, Chile.
6
Bioinformatics Program, Institute of Mathematics and Statistics, University of Sao Paulo, Brazil; Department of Radiology, School of Medicine, University of Sao Paulo, Brazil.
7
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil; Department of Psychiatry, University of São Paulo School of Medicine, São Paulo, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
8
Department of Radiology, School of Medicine, University of Sao Paulo, Brazil.
9
Institute of Psychiatry, King's College London, United Kingdom.
10
Department of Psychiatry, University of São Paulo School of Medicine, São Paulo, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.

Abstract

Functional brain hubs are key integrative regions in brain networks. Recently, brain hubs identified through resting-state fMRI have emerged as interesting targets to increase understanding of the relationships between large-scale functional networks and psychopathology. However, few studies have directly addressed the replicability and consistency of the hub regions identified and their association with symptoms. Here, we used the eigenvector centrality (EVC) measure obtained from graph analysis of two large, independent population-based samples of children and adolescents (7-15 years old; total N=652; 341 subjects for site 1 and 311 for site 2) to evaluate the replicability of hub identification. Subsequently, we tested the association between replicable hub regions and psychiatric symptoms. We identified a set of hubs consisting of the anterior medial prefrontal cortex and inferior parietal lobule/intraparietal sulcus (IPL/IPS). Moreover, lower EVC values in the right IPS were associated with psychiatric symptoms in both samples. Thus, low centrality of the IPS was a replicable sign of potential vulnerability to mental disorders in children. The identification of critical and replicable hubs in functional cortical networks in children and adolescents can foster understanding of the mechanisms underlying mental disorders.

KEYWORDS:

Children; Connectivity; Development; Replication; Resting state; fMRI

PMID:
27288820
DOI:
10.1016/j.dcn.2016.05.002
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center