Format

Send to

Choose Destination
Diabetes. 2016 Jul;65(7):1800-7. doi: 10.2337/db16-0251. Epub 2016 Jun 10.

De Novo Lipogenesis Products and Endogenous Lipokines.

Author information

1
Department of Genetics and Complex Diseases and Sabri √úlker Center, Harvard T.H. Chan School of Public Health, Boston, MA.
2
Department of Genetics and Complex Diseases and Sabri √úlker Center, Harvard T.H. Chan School of Public Health, Boston, MA Broad Institute of MIT and Harvard, Cambridge, MA ghotamis@hsph.harvard.edu.

Abstract

Recent studies have shown that in addition to their traditionally recognized functions as building blocks, energy stores, or hazardous intermediates, lipids also have the ability to act as signaling molecules with potent effects on systemic metabolism and metabolic diseases. This Perspective highlights this somewhat less apparent biology of lipids, especially focusing on de novo lipogenesis as a process that gives rise to key messenger molecules mediating interorgan communication. Elucidating the mechanisms of lipid-dependent coordination of metabolism promises invaluable insights into the understanding of metabolic diseases and may contribute to the development of a new generation of preventative and therapeutic approaches.

PMID:
27288005
PMCID:
PMC4915584
DOI:
10.2337/db16-0251
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center