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J Affect Disord. 2017 Dec 15;224:27-31. doi: 10.1016/j.jad.2016.05.054. Epub 2016 May 30.

Effects of omega-3 polyunsaturated fatty acids on psychophysiological symptoms of post-traumatic stress disorder in accident survivors: A randomized, double-blind, placebo-controlled trial.

Author information

1
Division of Bioengineering and Bioinformatics, Graduate School of Information Science and Technology, Hokkaido University, Kita 14 Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0814, Japan; CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.
2
CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan; School of Distance Learning, Department of Human Sciences, Musashino University, 1-1-20 Shin-machi, Nishitokyo, Tokyo 202-8585, Japan.
3
CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan; Department of Psychiatry, National Disaster Medical Center, 3256 Midori-cho, Tachikawa, Tokyo 190-0014, Japan; Department of Mental Health Policy and Evaluation, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187-8553, Japan.
4
CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan; (f)Department of Public Health, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.
5
CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan; (g)Toyama Jonan Onsen Daini Hospital, 1-13-6 Taromaru-nishi-machi, Toyama, Toyama 939-8271, Japan.
6
CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan; Department of Psychiatry, National Disaster Medical Center, 3256 Midori-cho, Tachikawa, Tokyo 190-0014, Japan; (h)Division of Health Care Research, Center for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Electronic address: yumatsuo@ncc.go.jp.

Abstract

BACKGROUND:

Psychophysiological symptoms (e.g., pounding heart) are known to be a prominent feature of post-traumatic stress disorder (PTSD). Although omega-3 polyunsaturated fatty acids (PUFAs) have a beneficial potential pharmacological effect of preventing these psychophysiological symptoms, no clinical data is yet available. Therefore, we conducted a randomized, double-blind, placebo-controlled trial of Japanese accident survivors.

METHODS:

A total of 83 participants received either omega-3 PUFAs (1470mg docosahexaenoic acid and 147mg eicosapentaenoic acid per day) or placebo within 10 days of the accidental injury. After 12-week supplementation, participants performed script-driven imagery of their traumatic event during monitoring of their heart rate and skin conductance.

RESULTS:

Analysis revealed that heart rate during both rest and script-driven imagery was significantly lower in the omega-3 group than the placebo group, whereas baseline heart rate was comparable between the two groups.

LIMITATIONS:

The present trial was conducted at a single-center in Japan and psychophysiological symptoms of PTSD in most participants were not serious.

CONCLUSION:

These findings suggest that post-trauma supplementation of omega-3 PUFAs might be effective for the secondary prevention of psychophysiological symptoms of PTSD.

KEYWORDS:

Arachidonic acid; Autonomic nerve; Aversive memory; Fish oil; Physiologic measures; n-3

PMID:
27287561
DOI:
10.1016/j.jad.2016.05.054
[Indexed for MEDLINE]

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