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Crit Rev Oncol Hematol. 2016 Aug;104:71-7. doi: 10.1016/j.critrevonc.2016.05.014. Epub 2016 May 26.

MicroRNA-1 properties in cancer regulatory networks and tumor biology.

Author information

1
Department of Urology, University Medicine Greifswald, Greifswald, Germany.
2
Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany.
3
Department of Urology, University Medicine Greifswald, Greifswald, Germany. Electronic address: matthias.stope@uni-greifswald.de.

Abstract

Short non-coding microRNAs have been identified to orchestrate crucial mechanisms in cancer progression and treatment resistance. MicroRNAs are involved in posttranscriptional modulation of gene expression and therefore represent promising targets for anticancer therapy. As mircoRNA-1 (miR-1) exerted to be predominantly downregulated in the majority of examined tumors, miR-1 is classified to be a tumor suppressor with high potential to diminish tumor development and therapy resistance. Here we review the complex functionality of miR-1 in tumor biology.

KEYWORDS:

Biomarker; Cancer; Cellular response; Resistance; microRNA-1

[Indexed for MEDLINE]

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