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Am J Alzheimers Dis Other Demen. 2016 Aug;31(5):437-42. doi: 10.1177/1533317516653820. Epub 2016 Jun 9.

Vascular Function in Alzheimer's Disease and Vascular Dementia.

Author information

1
Division of Neurology, Graduate School of Medicine, Kobe University, Chuo-ku, Kobe, Japan.
2
Division of Neurology, Graduate School of Medicine, Kobe University, Chuo-ku, Kobe, Japan washida@med.kobe-u.ac.jp.

Abstract

We investigated vascular functioning in patients with a clinical and radiological diagnosis of either Alzheimer's disease (AD) or vascular dementia (VaD) and examined a possible relationship between vascular function and cognitive status. Twenty-seven patients with AD, 23 patients with VaD, and 26 healthy control patients underwent measurements of flow-mediated dilation (FMD), ankle-brachial index (ABI), cardioankle vascular index (CAVI), and intima-media thickness (IMT). The FMD was significantly lower in patients with AD or VaD compared to controls. There were no significant differences in ABI, CAVI, or IMT among the 3 groups. A significant correlation was found between Mini-Mental State Examination (MMSE) scores and FMD. Furthermore, a multiple regression analysis revealed that FMD was significantly predicted by MMSE scores. These results suggest that endothelial involvement plays a role in AD pathogenesis, and FMD may be more sensitive than other surrogate methods (ABI, CAVI, and IMT) for detecting early-stage atherosclerosis and/or cognitive decline.

KEYWORDS:

Alzheimer’s disease; arterial stiffness; endothelial function; flow-mediated dilation; vascular dementia

PMID:
27284205
DOI:
10.1177/1533317516653820
[Indexed for MEDLINE]

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