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Trends Biochem Sci. 2016 Oct;41(10):821-823. doi: 10.1016/j.tibs.2016.05.009. Epub 2016 Jun 6.

A Cap for Every Occasion: Alternative eIF4F Complexes.

Author information

1
Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 31336, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 31336, USA.
2
Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 31336, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 31336, USA. Electronic address: stephenlee@med.miami.edu.

Abstract

The eukaryotic translation initiation factor 4F (eIF4F) has become essentially synonymous with 5' cap-dependent mRNA translation. Recent studies demonstrate that cells assemble variants of eIF4F to produce adaptive, cap-dependent translatomes during physiological conditions that inhibit eIF4F. These findings challenge us to reassess classical perceptions of cellular translational pathways.

KEYWORDS:

eIF4E; eIF4E2; eIF4F; eIF4G3; hypoxia; translation

PMID:
27283511
PMCID:
PMC5045779
DOI:
10.1016/j.tibs.2016.05.009
[Indexed for MEDLINE]
Free PMC Article

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