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Adv Mater. 2016 Sep;28(33):7129-36. doi: 10.1002/adma.201601902. Epub 2016 Jun 10.

Intelligent Albumin-MnO2 Nanoparticles as pH-/H2 O2 -Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy.

Author information

1
Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.

Abstract

A unique type of pH/H2 O2 dual-responsive intelligent nanoscale delivery system based on albumin-coated MnO2 is presented, which is capable of modulating the tumor microenvironment (TME) by relieving hypoxia. Additionally, TME-responsive size changes enable effective intratumor diffusion. A highly effective combined photodynamic and chemotherapy is realized with these nanoparticles in a mouse tumor model.

KEYWORDS:

albumin; combination therapies; deep penetration; manganese dioxide; tumor microenvironment

PMID:
27283434
DOI:
10.1002/adma.201601902

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