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Perit Dial Int. 2016 9-10;36(5):526-32. doi: 10.3747/pdi.2015.00090. Epub 2016 Jun 9.

The Trio Trial - A Randomized Controlled Clinical Trial Evaluating the Effect of a Biocompatible Peritoneal Dialysis Solution on Residual Renal Function.

Author information

1
Department of Nephrology, The Scarborough Hospital, Scarborough, ON, Canada tabosikaneta@yahoo.ca.
2
Department of Medicine, Credit Valley Hospital, Mississauga, ON, Canada.
3
Division of Radiology, Dalhousie University, Halifax, NS, Canada.
4
Research Department, Kidney Life Sciences Institute, Scarborough, ON, Canada.
5
Department of Nephrology, The Scarborough Hospital, Scarborough, ON, Canada.
6
Statistician, Private Statistics Consultants, Toronto, ON, Canada.
7
Medicine & Geriatrics, Princess Margaret Hospital, Hong Kong.
8
Department of Nephrology, University Health Network, Toronto, ON, Canada.

Abstract

BACKGROUND AND OBJECTIVE:

Residual renal function (RRF) correlates with mortality and morbidity rates in patients receiving peritoneal dialysis (PD). We examined the effect of a biocompatible PD solution (Gambrosol Trio; Gambro Lundia AB, Lund, Sweden) with lower concentrations of glucose degradation products on rates of decline in RRF. ♦

DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS:

Incident patients at 2 centers in Canada and 1 in Hong Kong were randomized (by minimization) in an open-label parallel group trial to receive Gambrosol Trio or standard PD solution (Dianeal; Baxter Healthcare, Mississauga, Canada) for 2 years. Primary outcome was slope of RRF. Secondary outcomes were urine volumes, fluid and nutrition indices, PD and membrane characteristics, peritonitis rates, adverse events, and PD technique survival. ♦

RESULTS:

Residual renal function declined by 0.132 mL/minute/1.73 m(2)/month in 51 patients allocated to biocompatible, and 0.174 mL/minute/1.73 m(2)/month in 50 patients allocated to standard PD solution (difference 0.042 mL/minute/1.73 m(2)/month, p = 0.001). Urine volume, body mass index, normalized protein catabolic rates, and fat mass were higher; total body water, peritoneal ultrafiltration, and D/P creatinine did not differ; and serum phosphate, rates of icodextrin, and automated cycler use were lower with Gambrosol Trio use. There were more peritonitis events with Gambrosol Trio use, while PD technique survival did not differ between groups. ♦

CONCLUSIONS:

The use of the biocompatible PD solution Gambrosol Trio was associated with slower rates of decline in RRF, fluid and nutrition benefits, and increased peritonitis rates.

TRIAL NUMBER:

ISRCTN26252543.

KEYWORDS:

Peritoneal dialysis; biocompatible PD solutions; peritonitis; residual renal function

PMID:
27282852
PMCID:
PMC5033628
DOI:
10.3747/pdi.2015.00090
[Indexed for MEDLINE]
Free PMC Article

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