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Clin Vaccine Immunol. 2016 Aug 5;23(8):732-4. doi: 10.1128/CVI.00028-16. Print 2016 Aug.

Comparison of Enzyme Immunoassays for Detection of Antibodies to Hepatitis D Virus in Serum.

Author information

1
Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
2
Focus Diagnostics Reference Laboratory, San Juan Capistrano, California, USA.
3
Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
4
Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA The Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA kjerome@fhcrc.org.

Abstract

Serology remains critical for diagnosing hepatitis D virus (HDV) infection, which affects 15 to 20 million people worldwide, but the literature on characterizing commercial enzyme immunoassays (EIAs) dates back to 15 years ago. We evaluated 2 commercial EIAs currently available for detecting anti-HDV antibodies. The DiaSorin assay demonstrated 100% sensitivity and specificity. Using a modified cutoff value, the Cusabio assay demonstrated a sensitivity of 81.3% and specificity of 90.9%. Our data show that recently developed EIAs are reliable for anti-HDV antibody detection.

PMID:
27280621
PMCID:
PMC4979180
DOI:
10.1128/CVI.00028-16
[Indexed for MEDLINE]
Free PMC Article

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