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Clin Interv Aging. 2016 May 19;11:571-8. doi: 10.2147/CIA.S98102. eCollection 2016.

Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study.

Author information

1
Cornea and Ocular Surface Department, Institut Català de Retina, Barcelona, Spain.

Abstract

PURPOSE:

To assess the benefits and tolerability of a dietary supplement based on omega-3 fatty acids to relieve dry eye symptoms.

METHODS:

A total of 1,419 patients (74.3% women, mean age 58.9 years) with dry eye syndrome using artificial tears participated in a 12-week prospective study. Patients were instructed to take 3 capsules/day of the nutraceutical formulation (Brudysec(®) 1.5 g). Study variables were dry eye symptoms (scratchy and stinging sensation, eye redness, grittiness, painful and tired eyes, grating sensation, and blurry vision), conjunctival hyperemia, tear breakup time (TBUT), Schrimer I test, and Oxford grading scheme.

RESULTS:

At 12 weeks, each dry eye symptom improved significantly (P<0.001), and the use of artificial tears decreased significantly from 3.77 (standard deviation [SD] =2.08) at baseline to 3.45 (SD =1.72) (P<0.01). In addition, the Schirmer test scores and the TBUT increased significantly, and there was an increase in patients grading 0-I in the Oxford scale and a decrease of those grading IV-V. Significant differences in improvements of dry eye symptoms were also found in compliant versus noncompliant patients as well as in those with moderate/severe versus none/mild conjunctival hyperemia.

CONCLUSION:

Oral ω-3 fatty acids supplementation was an effective treatment for dry eye symptoms.

KEYWORDS:

artificial tears; dry eye symptoms; eye discomfort; nutraceutical supplement; ocular inflammation; omega-3 polyunsaturated fatty acids

PMID:
27279739
PMCID:
PMC4878667
DOI:
10.2147/CIA.S98102
[Indexed for MEDLINE]
Free PMC Article

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