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Mov Disord. 2016 Sep;31(9):1414-7. doi: 10.1002/mds.26687. Epub 2016 Jun 9.

Motor features in Parkinson's disease with normal olfactory function.

Author information

1
Movement Disorders Section, Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI), Ciudad Autónoma de Buenos Aires, Argentina.
2
Movement Disorders Section, Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI), Ciudad Autónoma de Buenos Aires, Argentina. mmerello@fleni.org.ar.
3
Argentine National Scientific and Technological Research Council (CONICET), Buenos Aires, Argentina. mmerello@fleni.org.ar.

Abstract

BACKGROUND:

Normosmic Parkinson's disease (PD) might be a unique clinical phenotype with a more benign course when compared with hyposmic PD.

OBJECTIVE:

The objective of this study was to evaluate motor features and the acute levodopa response according to olfactory function.

METHODS:

A total of 169 de novo PD patients that underwent olfactory testing and acute levodopa challenge for clinical prediction of sustained long-term dopaminergic response were evaluated.

RESULTS:

The overall frequency of normosmia was 33%. Normosmic PD patients scored nonsignificantly different to hyposmic/anosmic patients on motor scale and on degree of improvement with levodopa. Motor scores at follow-up were comparable among groups.

CONCLUSIONS:

Normal olfactory function is common in early PD and was not associated with a different motor phenotype when compared with PD patients with olfactory dysfunction. © 2016 International Parkinson and Movement Disorder Society.

KEYWORDS:

Parkinson's disease; levodopa response; motor features; normosmia; olfaction

PMID:
27277396
DOI:
10.1002/mds.26687
[Indexed for MEDLINE]

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