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Nat Struct Mol Biol. 2016 Jun;23(6):481-6. doi: 10.1038/nsmb.3195. Epub 2016 Jun 7.

Nanodiscs for structural and functional studies of membrane proteins.

Author information

1
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
2
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

Abstract

Membrane proteins have long presented a challenge to biochemical and functional studies. In the absence of a bilayer environment, individual proteins and critical macromolecular complexes may be insoluble and may display altered or absent activities. Nanodisc technology provides important advantages for the isolation, purification, structural resolution and functional characterization of membrane proteins. In addition, the ability to precisely control the nanodisc composition provides a nanoscale membrane surface for investigating molecular recognition events.

PMID:
27273631
DOI:
10.1038/nsmb.3195
[Indexed for MEDLINE]

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