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Nat Struct Mol Biol. 2016 Jun 7;23(6):464-7. doi: 10.1038/nsmb.3215.

Atomic-level analysis of membrane-protein structure.

Author information

1
Department of Biochemistry and Molecular Biophysics and the Department of Physiology and Cellular Biophysics, Columbia University, New York, New York, USA, and at the New York Structural Biology Center (NYSBC), New York, New York, USA.

Abstract

Membrane proteins are substantially more challenging than natively soluble proteins as subjects for structural analysis. Thus, membrane proteins are greatly underrepresented in structural databases. Recently, focused consortium efforts and advances in methodology for protein production, crystallographic analysis and cryo-EM analysis have accelerated the pace of atomic-level structure determination of membrane proteins.

PMID:
27273628
PMCID:
PMC5299386
DOI:
10.1038/nsmb.3215
[Indexed for MEDLINE]
Free PMC Article

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