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Nat Commun. 2016 Jun 7;7:11596. doi: 10.1038/ncomms11596.

Th2 and eosinophil responses suppress inflammatory arthritis.

Author information

1
Department of Internal Medicine 3, University Hospital Erlangen and Friedrich Alexander University of Erlangen-Nuremberg, Gluckstrasse 6, Erlangen 91054, Germany.
2
Department of Rheumatology and Immunology, Anhui Medical University Affiliated Provincial Hospital, Hefei 230001, China.
3
Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU), Erlangen 91054, Germany.

Abstract

Th2-eosinophil immune responses are well known for mediating host defence against helminths. Herein we describe a function of Th2-eosinophil responses in counteracting the development of arthritis. In two independent models of arthritis, Nippostrongylus brasiliensis infection leads to Th2 and eosinophil accumulation in the joints associated with robust inhibition of arthritis and protection from bone loss. Mechanistically, this protective effect is dependent on IL-4/IL-13-induced STAT6 pathway. Furthermore, we show that eosinophils play a central role in the modulation of arthritis probably through the increase of anti-inflammatory macrophages into arthritic joints. The presence of these pathways in human disease is confirmed by detection of GATA3-positive cells and eosinophils in the joints of rheumatoid arthritis patients. Taken together, these results demonstrate that eosinophils and helminth-induced activation of the Th2 pathway axis effectively mitigate the course of inflammatory arthritis.

PMID:
27273006
PMCID:
PMC4899615
DOI:
10.1038/ncomms11596
[Indexed for MEDLINE]
Free PMC Article

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