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Int J Epidemiol. 2016 Aug;45(4):1135-1145. Epub 2016 Jun 6.

Trajectories of function and biomarkers with age: the CHS All Stars Study.

Author information

1
Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA newmana@edc.pitt.edu.
2
Harvard Affiliated Emergency Medicine Residency, Massachusetts General Hospital, and Brigham and Women's Hospital Department of Emergency Medicine, Boston, MA, USA.
3
Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, Bronx, NY, USA.
4
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
5
Department of Epidemiology, Oregon State University, Corvallis, OR, USA.
6
Department of Epidemiology, University of Miami, Miami, FL, USA.
7
Collaborative Health Studies Coordinating Center, University of Washington, Seattle, WA, USA.

Abstract

BACKGROUND:

Multimorbidity is a major driver of physical and cognitive impairment, but rates of decline are also related to ageing. We sought to determine trajectories of decline in a large cohort by disease status, and examined their correspondence with biomarkers of ageing processes including growth hormone, sex steroid, inflammation, visceral adiposity and kidney function pathways.

METHODS:

We have followed the 5888 participants in the Cardiovascular Health Study (CHS) for healthy ageing and longevity since 1989-90. Gait speed, grip strength, modified mini-mental status examination (3MSE) and the digit symbol substitution test (DSST) were assessed annually to 1998-99 and again in 2005-06. Insulin-like growth hormone (IGF-1), dehydroepiandrosterone sulphate (DHEAS), interleukin-6 (IL-6), adiponectin and cystatin-C were assessed 3-5 times from stored samples. Health status was updated annually and dichotomized as healthy vs not healthy. Trajectories for each function measure and biomarker were estimated using generalized estimating equations as a function of age and health status using standardized values.

RESULTS:

Trajectories of functional decline showed strong age acceleration late in life in healthy older men and women as well as in chronically ill older adults. Adiponectin, IL-6 and cystatin-C tracked with functional decline in all domains; cystatin-C was consistently associated with functional declines independent of other biomarkers. DHEAS was independently associated with grip strength and IL-6 with grip strength and gait speed trajectories.

CONCLUSIONS:

Functional decline in late life appears to mark a fundamental ageing process in that it occurred and was accelerated in late life regardless of health status. Cystatin C was most consistently associated with these functional declines.

KEYWORDS:

Ageing; biomarkers; cognitive function; disability; gait speed; grip strength

PMID:
27272182
PMCID:
PMC5841627
DOI:
10.1093/ije/dyw092
[Indexed for MEDLINE]
Free PMC Article

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