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Hepatol Int. 2017 Jan;11(1):45-53. doi: 10.1007/s12072-016-9743-4. Epub 2016 Jun 7.

Epigenetic mechanisms regulating the development of hepatocellular carcinoma and their promise for therapeutics.

Author information

1
Royal Hobart Hospital Tasmania, Hobart, Australia.
2
COMSATS Institute of Information Technology, Islamabad, Pakistan.
3
Department of Biochemistry, Abdul Wali Khan University Mardan, Mardan, 25200, Pakistan.
4
Western University, London, ON, Canada.
5
Children's Health Research Institute, London Health Sciences Centre, Western University, 800 Commissioners Rd E, Victoria Research Labs, London, ON, Canada. rmehmood@uwo.ca.

Abstract

Hepatocellular carcinoma (HCC) is one of the most common cancers around the globe and third most fatal malignancy. Chronic liver disorders such as chronic hepatitis and liver cirrhosis often lead to the development of HCC. Accumulation of genetic and epigenetic alterations are involved in the development of HCC. Genetic research sparked by recent developments in next generation sequencing has identified the frequency of genetic alterations that occur in HCC and has led to the identification of genetic hotspots. Emerging evidence suggests that epigenetic aberrations are strongly associated with the initiation and development of HCC. Various important genes encoding tumor suppressors including P16, RASSF1A, DLC-1, RUNX3 and SOCS-1 are targets of epigenetic dysregulation during the development of HCC. The present review discusses the importance of epigenetic regulations including DNA methylation, histone modification and microRNA mediated regulation of gene expression during tumorigenesis and their use as disease biomarkers. Furthermore, these epigenetic alterations have been discussed in relationship with promising therapeutic perspectives for HCC and related cancers.

KEYWORDS:

Epi-drugs; Epigenetic regulation; HCC; Hepatocarcinogenesis; Therapeutics; Tumor suppressors

PMID:
27271356
DOI:
10.1007/s12072-016-9743-4
[Indexed for MEDLINE]

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