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CA Cancer J Clin. 2016 Sep;66(5):408-36. doi: 10.3322/caac.21350. Epub 2016 Jun 6.

Current concepts in the diagnosis and pathobiology of intraepithelial neoplasia: A review by organ system.

Author information

1
Assistant Professor of Pathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.
2
Associate Professor of Pathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.
3
Professor of Pathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.
4
Assistant Professor of Dermatology, Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, MD.
5
Professor of Urology, Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD.
6
Professor of Pathology, Department of Pathology, University of Virginia Health System, Charlottesville, VA.
7
Associate Professor of Dermatology and Pathology, Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, MD.

Abstract

Answer questions and earn CME/CNE In this report, a team of surgical pathologists has provided a review of intraepithelial neoplasia in a host of (but not all) anatomic sites of interest to colleagues in various medical specialties, namely, uterine cervix, ovary, breast, lung, head and neck, skin, prostate, bladder, pancreas, and esophagus. There is more experience with more readily accessible sites (such as the uterine cervix and skin) than with other anatomic sites, and the lack of uniform terminology, together with divergent biology in various sites, makes it difficult to paint a unifying, relevant portrait. The authors' aim was to provide a framework from which to move forward as we care for patients with such precancerous lesions. CA Cancer J Clin 2016;66:408-436.

KEYWORDS:

carcinoma in situ; dysplasia; intraepithelial neoplasia; precancer; preinvasive neoplasia

PMID:
27270763
DOI:
10.3322/caac.21350
[Indexed for MEDLINE]
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