Format

Send to

Choose Destination
Nat Genet. 2016 Jul;48(7):817-20. doi: 10.1038/ng.3583. Epub 2016 Jun 6.

Haplotype estimation for biobank-scale data sets.

Author information

1
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
2
Department of Statistics, University of Oxford, Oxford, UK.
3
Department of Health Sciences, University of Leicester, Leicester, UK.
4
School of Medicine, University of Nottingham, Nottingham, UK.
5
Chaire de Bioinformatique, Laboratoire Génomique, Bioinformatique et Applications (Equipe d'Accueil 4627), Conservatoire National des Arts et Métiers, Paris, France.
6
Département de Génétique et Développement, University of Geneva, Geneva, Switzerland.

Abstract

The UK Biobank (UKB) has recently released genotypes on 152,328 individuals together with extensive phenotypic and lifestyle information. We present a new phasing method, SHAPEIT3, that can handle such biobank-scale data sets and results in switch error rates as low as ∼0.3%. The method exhibits O(NlogN) scaling with sample size N, enabling fast and accurate phasing of even larger cohorts.

PMID:
27270105
PMCID:
PMC4926957
DOI:
10.1038/ng.3583
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center