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Nat Commun. 2016 Jun 7;7:11800. doi: 10.1038/ncomms11800.

Simultaneous optical and electrical in vivo analysis of the enteric nervous system.

Author information

1
School of Electrical and Computer Engineering, Cornell University, Ithaca, New York 14853, USA.
2
Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA.
3
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.
4
Center for Neurogastroenterology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.
5
Solomon H. Snyder Department of Neuroscience, Department of Neurosurgery, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
6
Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.

Abstract

The enteric nervous system (ENS) is a major division of the nervous system and vital to the gastrointestinal (GI) tract and its communication with the rest of the body. Unlike the brain and spinal cord, relatively little is known about the ENS in part because of the inability to directly monitor its activity in live animals. Here, we integrate a transparent graphene sensor with a customized abdominal window for simultaneous optical and electrical recording of the ENS in vivo. The implanted device captures ENS responses to neurotransmitters, drugs and optogenetic manipulation in real time.

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PMID:
27270085
PMCID:
PMC4899629
DOI:
10.1038/ncomms11800
[Indexed for MEDLINE]
Free PMC Article

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