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Hum Vaccin Immunother. 2016 Sep;12(9):2351-6. doi: 10.1080/21645515.2016.1177688. Epub 2016 Jun 7.

Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus.

Author information

1
a Departments of Microbiology and Immunology , University of Texas Medical Branch , Galveston , TX , USA.
2
e Department of Medical Laboratories Technology , College of Applied Medical Sciences, Jazan University , Jazan , Saudi Arabia.
3
b Pathology, University of Texas Medical Branch , Galveston , TX , USA.
4
c Internal Medicine, Division of Infectious Disease, University of Texas Medical Branch , Galveston , TX , USA.
5
d Center for Biodefense and Emerging Infectious Disease, University of Texas Medical Branch , Galveston , TX , USA.

Abstract

To determine if a hypersensitive-type lung pathology might occur when mice were given an inactivated MERS-CoV vaccine and challenged with infectious virus as was seen with SARS-CoV vaccines, we prepared and vaccinated mice with an inactivated MERS-CoV vaccine. Neutralizing antibody was induced by vaccine with and without adjuvant and lung virus was reduced in vaccinated mice after challenge. Lung mononuclear infiltrates occurred in all groups after virus challenge but with increased infiltrates that contained eosinophils and increases in the eosinophil promoting IL-5 and IL-13 cytokines only in the vaccine groups. Inactivated MERS-CoV vaccine appears to carry a hypersensitive-type lung pathology risk from MERS-CoV infection that is similar to that found with inactivated SARS-CoV vaccines from SARS-CoV infection.

KEYWORDS:

coronavirus; Eosinophils; immunopathology; Middle East Respiratory Syndrome; vaccination

PMID:
27269431
PMCID:
PMC5027702
DOI:
10.1080/21645515.2016.1177688
[Indexed for MEDLINE]
Free PMC Article

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