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Cell Rep. 2016 Jun 14;15(11):2323-30. doi: 10.1016/j.celrep.2016.05.074. Epub 2016 Jun 3.

The IFITMs Inhibit Zika Virus Replication.

Author information

  • 1Department of Microbiology and Physiological Systems (MaPS), University of Massachusetts Medical School, Worcester, MA 01655, USA.
  • 2Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
  • 3Department of Microbiology and Physiological Systems (MaPS), University of Massachusetts Medical School, Worcester, MA 01655, USA; Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: abraham.brass@umassmed.edu.

Abstract

Zika virus has emerged as a severe health threat with a rapidly expanding range. The IFITM family of restriction factors inhibits the replication of a broad range of viruses, including the closely related flaviruses West Nile virus and dengue virus. Here, we show that IFITM1 and IFITM3 inhibit Zika virus infection early in the viral life cycle. Moreover, IFITM3 can prevent Zika-virus-induced cell death. These results suggest that strategies to boost the actions and/or levels of the IFITMs might be useful for inhibiting a broad range of emerging viruses.

KEYWORDS:

IFITM; IFITM1; IFITM3; Zika virus; flavivirus; host factors; interferon; intrinsic immunity

PMID:
27268505
DOI:
10.1016/j.celrep.2016.05.074
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