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Nefrologia. 2016 Jul-Aug;36(4):347-53. doi: 10.1016/j.nefro.2016.04.001. Epub 2016 Jun 3.

Hyperchloremia - Why and how.

[Article in English, Spanish]

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Nephrology Section, Department of Medicine, VA Greater Los Angeles Healthcare System and David Geffen School of Medicine at UCLA, United States. Electronic address:


Hyperchloremia is a common electrolyte disorder that is associated with a diverse group of clinical conditions. The kidney plays an important role in the regulation of chloride concentration through a variety of transporters that are present along the nephron. Nevertheless, hyperchloremia can occur when water losses exceed sodium and chloride losses, when the capacity to handle excessive chloride is overwhelmed, or when the serum bicarbonate is low with a concomitant rise in chloride as occurs with a normal anion gap metabolic acidosis or respiratory alkalosis. The varied nature of the underlying causes of the hyperchloremia will, to a large extent, determine how to treat this electrolyte disturbance.


Alteración electrolítica; Bicarbonato sérico; Electrolyte disorder; Hipercloremia; Hyperchloremia; Serum bicarbonate

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