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Curr Probl Pediatr Adolesc Health Care. 2016 Jul;46(7):213-228. doi: 10.1016/j.cppeds.2016.04.002. Epub 2016 Jun 2.

Pediatric Malignant Bone Tumors: A Review and Update on Current Challenges, and Emerging Drug Targets.

Author information

1
Division of Pediatric Hematology Oncology, NYU Langone Medical Center, New York, NY. Electronic address: Twana.Jackson@nyumc.org.
2
Department of Radiology, NYU Langone Medical Center, New York, NY.
3
Division of Pediatric Hematology Oncology, NYU Langone Medical Center, New York, NY.

Abstract

Osteosarcoma (OS) and the Ewing sarcoma family of tumors (ESFT) are the most common malignant bone tumors in children and adolescents. While significant improvements in survival have been seen in other pediatric malignancies the treatment and prognosis for pediatric bone tumors has remained unchanged for the past 3 decades. This review and update of pediatric malignant bone tumors will provide a general overview of osteosarcoma and the Ewing sarcoma family of tumors, discuss bone tumor genomics, current challenges, and emerging drug targets.

PMID:
27265835
DOI:
10.1016/j.cppeds.2016.04.002
[Indexed for MEDLINE]

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