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Bull Exp Biol Med. 2016 May;161(1):45-9. doi: 10.1007/s10517-016-3341-2. Epub 2016 Jun 6.

Psychopharmacological Effects of Alkaloid Z77 under Conditions of Posthypoxic Encephalopathy and Mechanisms of Their Development.

Author information

1
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. zgn@pharm.tsu.ru.
2
Tomsk National Research State University, Tomsk, Russia. zgn@pharm.tsu.ru.
3
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
4
Tomsk National Research State University, Tomsk, Russia.

Abstract

Psychopharmacological effects of atisine-type diterpene alkaloid Z77 were studied under conditions of experimental posthypoxic encephalopathy. The preparation had a pronounced cerebroprotective effect consisting in normalization of orientation and exploratory behavior and conditioned activity in experimental animals. These changes were accompanied by significant increase in the number of neural stem cells in the paraventricular region of the brain and markedly enhanced production of neurotrophic growth factors by neural tissue microenvironment cells.

KEYWORDS:

alkaloids; cerebroprotective preparations; hypoxia; neural stem cells; regenerative medicine

PMID:
27265139
DOI:
10.1007/s10517-016-3341-2
[Indexed for MEDLINE]

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