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Bull Exp Biol Med. 2016 May;161(1):58-60. doi: 10.1007/s10517-016-3344-z. Epub 2016 Jun 6.

Dipeptide Piracetam Analogue Noopept Improves Viability of Hippocampal HT-22 Neurons in the Glutamate Toxicity Model.

Author information

1
V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
2
V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. cergej.nikolajev@gmail.com.

Abstract

Effect of noopept (N-phenylacetyl-prolylglycine ethyl ester) on viability of neurons exposed to neurotoxic action of glutamic acid (5 mM) was studied in vitro in immortalized mouse hippocampal HT-22 neurons. Noopept added to the medium before or after glutamic acid improved neuronal survival in a concentration range of 10-11-10-5 M. Comparison of the effective noopept concentrations determined in previous studies on cultured cortical and cerebellar neurons showed that hippocampal neurons are more sensitive to the protective effect of noopept.

KEYWORDS:

HT-22 culture; dipeptides; glutamate toxicity; neuroprotection; noopept

PMID:
27265136
DOI:
10.1007/s10517-016-3344-z
[Indexed for MEDLINE]

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