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Magn Reson Imaging. 2016 Oct;34(8):1220-5. doi: 10.1016/j.mri.2016.05.013. Epub 2016 Jun 1.

MRI-based estimation of liver function by intravoxel incoherent motion diffusion-weighted imaging.

Author information

1
Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
2
Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou, China.
3
Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
4
Philips Healthcare, Guangzhou 18F, Tower B, CIC No.33 Zhongshan san Road, YueXiu District, Guangzhou, China.
5
Philips Healthcare, Science Park East Avenue, Hong Kong Science Park, New Territories, Hong Kong.
6
Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address: yikai.xu@163.com.

Abstract

PURPOSE:

To explore the usefulness of intravoxel incoherent motion (IVIM) to evaluate the hepatic functional reserve as expressed by the model for Child-Pugh class.

MATERIALS AND METHODS:

IVIM diffusion-weighted imaging (DWI) using 10 different b values were performed on a Philips 3.0T MR scanner in 70 patients with liver cirrhosis and 60 healthy volunteers as the control group. Patients with liver cirrhosis were subdivided into three groups: Child-Pugh class A: 29 cases; Child-Pugh class B: 19 cases; Child-Pugh class C: 22 cases. Pure molecular diffusion (D), pseudo-diffusion (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) values were calculated, and used to determine liver function, as indicated by the Child-Pugh class.

RESULTS:

The ICC values of D, D*, f and ADC between two radiologists were 0.997, 0.986, 0.985 and 0.995, respectively. D*, f and ADC values of liver cirrhosis group were significantly lower than control group (P<0.001, P=0.016, P=0.042, respectively). D*, f and ADC values significantly decreased with increasing Child-Pugh scores (p<0.05). Child-Pugh scores were inversely correlated with D* and f values (r=-0.423, r=-0.620, respectively). The areas under the curve (AUCs) of D* and f for evaluating liver function were 0.67-0.90 and 0.78-0.89, respectively.

CONCLUSION:

IVIM DWI may be a useful image-based method for assessing liver function.

KEYWORDS:

Child–Pugh class; DWI; Intravoxel incoherent motion; Liver function

PMID:
27262828
DOI:
10.1016/j.mri.2016.05.013
[Indexed for MEDLINE]

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